Get to know if Kids get Allergies

By Allergy News
In News
Mar 17th, 2016

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The Science Mag website has recently published an article about determining an allergy through blood cell. Learn why kids develops such allergies with some scientific explanation to sharpen  our understanding. Then, find out how the new study works and its outcome through reading this article.

This article was published on their website:

Some kids can scarf peanuts by the handful, but a single nut can kill others. A new study suggests one reason why children develop sometimes lethal food allergies. At birth, their blood is rich in cells that can promote a hyperactive immune response.

Past studies of some of the roughly 6 million U.S. kids who develop food allergies suggest that abnormalities start brewing early. By sampling the baby’s blood from the umbilical cord, researchers can get an early snapshot of the child’s immune system. They’ve found that blood from kids who later develop food allergies contains more chemical signals that promote inflammation and lower-than-normal concentrations of natural regulatory T cells, which tone down immune system responses.

To understand which changes might be key to allergy development, immunologist Yuxia Zhang of the Walter and Eliza Hall Institute of Medical Research in Parkville, Australia, and colleagues recruited more than 1000 newborns. The researchers analyzed immune cells in samples of the kids’ umbilical cord blood. Then, when the children were 1 year old, the team tested whether they were allergic to a range of foods, including eggs, cow’s milk, and peanuts.

The toddlers who had food allergies also showed higher numbers of a type of white blood cell called a monocyte at birth. Monocytes form the immune system’s reserves. When we get sick, they transform into cells such as macrophages that battle pathogens. Zhang and colleagues found that monocytes from the allergy-prone kids weren’t just more numerous, they were also hyperactive, reacting more vigorously to a bacterial molecule than did monocytes from allergy-free children. In other words, they responded more aggressively to apparent threats than did monocytes in the toddlers who didn’t develop allergies.

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